X-linked progressive retinal atrophy, type 3(XLPRA3)
Also known as: X-linked progressive retinal atrophy 3 · X-linked PRA type 3 · X-chromosomale progressive Retinaatrophie Typ 3 · Geschlechtsgebundene progressive Retinaatrophie 3 · Retinal atrophy, progressive, X-linked, type 3
Overview
What it is
This is an inherited eye disease where the light-sensitive cells of the retina, which is the back part of the eye, gradually break down. Because the genetic defect is carried on the X chromosome, male dogs are primarily affected by vision loss, while female dogs are typically unaffected carriers. Since the specific genetic mutation is currently unknown, there is no DNA test, and diagnosis relies on specialist clinical eye examinations.
How it presents
Owners typically first notice signs of night blindness, such as hesitancy or bumping into objects in the dark, starting in early to middle adulthood. As the disease progresses, the vision loss extends to daylight hours, eventually leading to complete blindness.
Treatment
There is no cure for this progressive condition, and management focuses on supportive care to help the dog adapt to vision loss. Lifetime costs for diagnostic eye examinations and supportive aids typically range from 400 to 1500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is X-linked progressive retinal atrophy, type 3?
This is an inherited eye disease where the light-sensitive cells of the retina, which is the back part of the eye, gradually break down. Because the genetic defect is carried on the X chromosome, male dogs are primarily affected by vision loss, while female dogs are typically unaffected carriers. Since the specific genetic mutation is currently unknown, there is no DNA test, and diagnosis relies on specialist clinical eye examinations.
How is X-linked progressive retinal atrophy, type 3 tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.