X-linked progressive retinal atrophy, type 2(XLPRA2)
Also known as: X-linked Progressive Retinal Atrophy 2 · Progressive Retinal Atrophy X-linked 2 · X-gebundene progressive Retinaatrophie Typ 2 · RPGR-associated progressive retinal atrophy type 2 · Retinal atrophy, progressive, X-linked, type 2
Overview
What it is
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. Due to a genetic defect on the X-chromosome, the cells of the retina progressively degenerate and die. Because of this X-linked inheritance pattern, the condition almost exclusively affects male dogs.
How it presents
Owners may first notice signs of night blindness, such as hesitation or bumping into objects in dim light, starting as early as six weeks of age. The disease progresses rapidly, typically leading to complete blindness by one to two years of age.
Treatment
There is no cure or treatment to stop the progression of this disease. Veterinary care focuses on diagnostic testing and supporting the dog's transition to blindness, with lifetime management costs typically ranging from 500 to 1500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is X-linked progressive retinal atrophy, type 2?
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. Due to a genetic defect on the X-chromosome, the cells of the retina progressively degenerate and die. Because of this X-linked inheritance pattern, the condition almost exclusively affects male dogs.
How is X-linked progressive retinal atrophy, type 2 tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.