X-linked progressive retinal atrophy, type 1(XLPRA1)
Also known as: X-linked progressive retinal atrophy 1 · X-linked PRA type 1 · Progressive retinal atrophy X-linked 1 · RPGR-associated progressive retinal atrophy · Retinal atrophy, progressive, X-linked, type 1
Overview
What it is
X-linked progressive retinal atrophy type 1 (XLPRA1) is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. Because the genetic mutation is located on the X chromosome, male dogs are primarily affected and will experience progressive vision loss.
How it presents
Owners usually first notice night blindness or difficulty navigating in low light when the dog is between 1 and 2 years of age. Over time, daytime vision also deteriorates, typically resulting in complete blindness by middle age.
Treatment
There is no cure for this condition, meaning treatment is lifelong and focuses on supportive care and regular veterinary eye exams. The lifetime cost for monitoring and supportive care typically ranges from 500 to 2500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is X-linked progressive retinal atrophy, type 1?
X-linked progressive retinal atrophy type 1 (XLPRA1) is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. Because the genetic mutation is located on the X chromosome, male dogs are primarily affected and will experience progressive vision loss.
How is X-linked progressive retinal atrophy, type 1 tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.