Retinal and skeletal dysplasia(OSD)
Also known as: Oculo-skeletal dysplasia · Oculoskeletal Dysplasia · Dwarfism with Retinal Dysplasia · DRD · Retinale und skeletale Dysplasie · …
Overview
What it is
This inherited condition affects both the skeletal system and the eyes due to abnormal tissue development. In the skeleton, it causes dwarfism with abnormally short limbs, while in the eyes, it leads to malformations of the retina, which is the light-sensitive layer at the back of the eye. These retinal changes can eventually cause the retina to detach, leading to vision loss.
How it presents
Owners will typically notice that affected puppies have abnormally short front legs starting in their first few weeks of life. As they grow, these dogs often develop painful joint problems and show signs of vision loss or complete blindness, usually within their first year.
Treatment
There is no cure for this condition, so treatment focuses on lifelong management of joint pain and supporting the dog's mobility and vision loss. Lifetime veterinary care, pain medications, and supportive therapies typically cost between 1,500 and 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Oculoskeletal Dysplasia 1 (OSD1) DNA-Test(OSD1)
Primary testDNA testEin molekularbiologischer Gentest zum Nachweis der verantwortlichen Mutation im COL9A3-Gen, um betroffene Hunde und symptomfreie Träger zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Oculoskeletal Dysplasia 2 (OSD2) DNA-Test(OSD2)
Primary testDNA testDieser DNA-Test identifiziert die ursächliche Mutation im COL9A2-Gen bei Samojeden, um betroffene Hunde und symptomfreie Anlageträger (Carrier) sicher zu bestimmen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Retinal and skeletal dysplasia?
This inherited condition affects both the skeletal system and the eyes due to abnormal tissue development. In the skeleton, it causes dwarfism with abnormally short limbs, while in the eyes, it leads to malformations of the retina, which is the light-sensitive layer at the back of the eye. These retinal changes can eventually cause the retina to detach, leading to vision loss.
How is Retinal and skeletal dysplasia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Oculoskeletal Dysplasia 1 (OSD1) DNA-Test, Oculoskeletal Dysplasia 2 (OSD2) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.