Retinal dysplasia, NDP-related
Also known as: Norrie Disease Protein-related retinal dysplasia · X-linked retinal dysplasia · NDP-RD · Norrie-Syndrom beim Hund · X-chromosomale Netzhautdysplasie
Overview
What it is
This is an inherited eye disorder where the retina—the light-sensitive tissue at the back of the eye—fails to develop properly due to a genetic mutation in the NDP gene. This malformation can lead to early detachment of the retina from the underlying tissue, which severely disrupts how visual signals are sent to the brain. Because the condition is X-linked, it primarily affects male dogs.
How it presents
Symptoms are typically noticeable in puppies shortly after they first open their eyes, around two to three weeks of age. Owners may observe signs of severe vision loss or complete blindness, such as bumping into objects, hesitation in unfamiliar spaces, or a cloudy appearance inside the pupil.
Treatment
There is no cure for this genetic condition, and the resulting blindness is lifelong. Veterinary care focuses on the initial diagnosis and monitoring for secondary issues like glaucoma, with expected lifetime costs ranging from 0 to 500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Retinal dysplasia, NDP-related?
This is an inherited eye disorder where the retina—the light-sensitive tissue at the back of the eye—fails to develop properly due to a genetic mutation in the NDP gene. This malformation can lead to early detachment of the retina from the underlying tissue, which severely disrupts how visual signals are sent to the brain. Because the condition is X-linked, it primarily affects male dogs.
How is Retinal dysplasia, NDP-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.