Progressive Retinal Atrophy (PRA), CNGB1-related(PRA-CNGB1)
Also known as: CNGB1-PRA · Progressive Retinal Atrophy CNGB1-related · CNGB1 progressive retinal atrophy · Progressive Netzhautatrophie (CNGB1) · CNGB1-related progressive retinal atrophy · …
Overview
What it is
This is an inherited eye disease where a genetic mutation in the CNGB1 gene causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Over time, these photoreceptor cells, which are responsible for capturing light and sending visual signals to the brain, stop functioning and die off. This leads to a progressive and permanent loss of vision in both eyes.
How it presents
Owners typically first notice night blindness or difficulty navigating in dim light during early to middle adulthood. As the disease advances, the dog's daytime vision also deteriorates, eventually leading to complete blindness.
Treatment
There is no cure for this condition, and the resulting blindness is permanent but painless. Management focuses on supportive care and regular veterinary ophthalmologist exams, with lifetime costs typically ranging from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
pap-PRA1 DNA-Test(pap-PRA1)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der pap-PRA1-Mutation im CNGB1-Gen bei Papillons und Phalènes zur Identifikation von freien, Träger- und betroffenen Hunden.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), CNGB1-related?
This is an inherited eye disease where a genetic mutation in the CNGB1 gene causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Over time, these photoreceptor cells, which are responsible for capturing light and sending visual signals to the brain, stop functioning and die off. This leads to a progressive and permanent loss of vision in both eyes.
How is Progressive Retinal Atrophy (PRA), CNGB1-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), pap-PRA1 DNA-Test, Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Phalene, Continental Toy Spaniel, Continental Toy Spaniel (Papillon).