Progressive Retinal Atrophy, Rod-Cone Dysplasia 2(PRA-rcd2)
Also known as: Rod-cone dysplasia 2 · rcd2-PRA · Early-onset PRA in Collies · Progressive Retinal Atrophy rcd2 · RD3-associated PRA · …
Overview
What it is
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. In affected dogs, the photoreceptors—the specialized cells that detect light—develop abnormally during puppyhood and prematurely waste away. This progressive degeneration leads to a complete and permanent loss of vision.
How it presents
Owners typically notice night blindness in affected puppies as early as six weeks of age, causing them to hesitate or bump into things in the dark. As the disease progresses, daytime vision also deteriorates, usually resulting in complete blindness by about one year of age.
Treatment
There is no cure or treatment to stop this progressive blindness. Lifetime costs generally range from 250 to 1200 EUR, which primarily covers veterinary ophthalmologist consultations and supportive aids to help the blind dog navigate daily life safely.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
rcd2-PRA DNA-Test(rcd2-PRA)
Primary testDNA testEin molekulargenetischer Test zum Nachweis der Mutation im RD3-Gen, die für die rcd2-Form der Progressiven Retinaatrophie beim Collie verantwortlich ist.
Issuing body: Optigen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy, Rod-Cone Dysplasia 2?
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. In affected dogs, the photoreceptors—the specialized cells that detect light—develop abnormally during puppyhood and prematurely waste away. This progressive degeneration leads to a complete and permanent loss of vision.
How is Progressive Retinal Atrophy, Rod-Cone Dysplasia 2 tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), ECVO Augenuntersuchung (DOK), rcd2-PRA DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: American Collie, Smooth Collie.