Cataract, CPT1A-related
Also known as: CPT1A cataract · Carnitine palmitoyltransferase 1A cataract · CPT1A-associated hereditary cataract · Grauer Star (CPT1A-assoziiert) · Hereditärer Katarakt (CPT1A)
Overview
What it is
This condition is an inherited eye disorder linked to a defect in the CPT1A gene, which is involved in cellular fat metabolism. The genetic variation causes the lens of the eye to lose its natural transparency and gradually become cloudy. This cloudiness prevents light from passing through the lens to the back of the eye, progressively impairing the dog's vision.
How it presents
Owners will typically notice a cloudy or greyish-white appearance within the dog's pupils, which usually begins to develop at a young age. As the cloudiness worsens, the dog may show signs of vision impairment, such as bumping into objects or hesitating in low-light conditions.
Treatment
While the underlying genetic cause cannot be cured, vision can be restored through a one-time surgical procedure to remove the cloudy lenses. This specialized surgery is highly effective and typically costs between 2,000 and 6,000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cataract, CPT1A-related?
This condition is an inherited eye disorder linked to a defect in the CPT1A gene, which is involved in cellular fat metabolism. The genetic variation causes the lens of the eye to lose its natural transparency and gradually become cloudy. This cloudiness prevents light from passing through the lens to the back of the eye, progressively impairing the dog's vision.
How is Cataract, CPT1A-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.