Primary open-angle glaucoma, ADAMTS10-related(POAG)
Also known as: Primary Open Angle Glaucoma · ADAMTS10-related POAG · Primäres Weitwinkelglaukom · Grüner Star
Overview
What it is
Primary open-angle glaucoma is an inherited eye disease caused by a genetic mutation that impairs the normal drainage of fluid, known as aqueous humor, from the eye. This fluid buildup leads to a gradual, painful increase in pressure within the eyeball. Over time, this elevated pressure damages the optic nerve, leading to progressive vision loss.
How it presents
The condition typically begins to show signs between 2 and 5 years of age. Owners may notice red eyes, dilated pupils that do not shrink in bright light, and a cloudy appearance over the surface of the eye.
Treatment
While there is no cure, the disease requires lifelong management with daily pressure-lowering eye drops and regular veterinary monitoring. In advanced cases, surgical removal of the eye may be required to relieve pain, with lifetime treatment costs ranging from €2,000 to €7,000.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Primary open-angle glaucoma, ADAMTS10-related?
Primary open-angle glaucoma is an inherited eye disease caused by a genetic mutation that impairs the normal drainage of fluid, known as aqueous humor, from the eye. This fluid buildup leads to a gradual, painful increase in pressure within the eyeball. Over time, this elevated pressure damages the optic nerve, leading to progressive vision loss.
How is Primary open-angle glaucoma, ADAMTS10-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Basset Artésien Normand, Small Schwyz Hound.