Dental-skeletal-retinal anomaly(DSRA)
Also known as: Dental skeletal retinal anomaly · MIA3-related anomaly · DSRA syndrome · Zahn-Skelett-Netzhaut-Anomalie · MIA3-related dental-skeletal-retinal anomaly · …
Overview
What it is
Dentale-skeletale-retinale Anomalie (DSRA) is a severe, inherited systemic disease that affects multiple organ systems, specifically the teeth, bones, and the retina, which is the light-sensitive tissue at the back of the eye. It is caused by a genetic mutation that disrupts the normal development and structure of these essential tissues. This disruption prevents the skeleton, teeth, and eyes from forming and functioning properly.
How it presents
Symptoms typically become noticeable in puppyhood. Owners may observe abnormally discolored, brittle teeth, stunted or delayed bone growth, and a progressive loss of vision that eventually leads to blindness.
Treatment
There is no cure for this condition, and treatment is limited to supportive care to manage symptoms. Lifelong management and palliative care typically cost between 1,000 and 4,000 EUR, though the severe progression of the disease often leads to early euthanasia.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Dental-skeletal-retinal anomaly?
Dentale-skeletale-retinale Anomalie (DSRA) is a severe, inherited systemic disease that affects multiple organ systems, specifically the teeth, bones, and the retina, which is the light-sensitive tissue at the back of the eye. It is caused by a genetic mutation that disrupts the normal development and structure of these essential tissues. This disruption prevents the skeleton, teeth, and eyes from forming and functioning properly.
How is Dental-skeletal-retinal anomaly tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Cane Corso.