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Health Testing Guide
Which tests are mandatory, how to spot responsible breeders — and what it costs when things go wrong.
For the Great Dane we have compiled 1 mandatory and 11 recommended health tests, drawn from breed-club regulations, the University of PEI (CIDD), and OMIA — weighted by severity and heritability.
What this grade means
The Great Dane receives an E grade due to its very short life expectancy and susceptibility to serious health conditions. Dilated cardiomyopathy (DCM) and acute gastric dilatation-volvulus (GDV) are particularly critical risks for these giants. In addition, orthopedic issues such as hip dysplasia (HD) place a massive strain on their musculoskeletal system.
Every breed is susceptible to certain inherited conditions. Just like humans, dogs inherit predispositions from their parents. Responsible breeders screen their breeding dogs for these conditions and make informed mating decisions to reduce the risk passed on to puppies.
No — but it's the strongest tool we have. Diet, exercise, environment, and genetics all contribute to whether a dog develops a condition. When breeders use the right tests to identify risk in potential parents, the likelihood of many conditions appearing in the puppies drops significantly.
There's no one-size-fits-all here. For the Great Dane we track 1 mandatory tests plus 11 additional recommended ones. The specific tests and passing thresholds are detailed further below.
Keep in mind
Reliable screening tests still don't exist for many hereditary conditions, and tests for complex polygenic conditions are not always predictive of severity in the puppies. Even so, they're a powerful tool used by every responsible breeder.
There are two main types of health tests:
Screen the dog's DNA for known disease-causing mutations. Can be performed from puppyhood and give a binary result (clear / carrier / affected).
Clinical and imaging exams like X-ray, ultrasound, or ophthalmoscopy. They show how a predisposition actually manifests — usually only conclusive after 12–18 months.
We group breeding programs into three levels based on testing depth. Ask your breeder directly which level they meet.
A breeder at the Great level performs all mandatory tests plus 11 additional clinically recommended screenings that reduce risk in this breed.
In addition to mandatory tests:
Gastric dilatation-volvulus(GDV)
Andere
Gastric dilatation-volvulus, commonly known as bloat, is a severe condition affecting the stomach and digestive system. It occurs when the stomach fills with gas and twists on itself, trapping the gas and blocking blood flow to vital organs. This twisting can rapidly lead to tissue damage and cardiovascular shock if not treated immediately.
Roentgen · Passing: A
Primary Open-Angle Glaucoma(POAG)
Augen und Sehvermögen
Primary open-angle glaucoma is an inherited eye disease where the natural fluid inside the eye cannot drain properly. This fluid buildup causes a gradual increase in pressure within the eyeball, which eventually damages the optic nerve, the connection between the eye and the brain. Without management, this pressure leads to permanent blindness.
Augen · Passing: CLEAR
Cataract(HC)
Augen und Sehvermögen
A cataract is a progressive clouding of the lens inside the dog's eye, which is the clear structure that focuses light onto the retina at the back of the eye. When the lens becomes cloudy or opaque, it blocks light from entering, gradually impairing the dog's vision. If left untreated, this condition can eventually lead to complete blindness in the affected eye.
Augen · Passing: CLEAR
Cervical vertebral compressive myelopathy(CVCM)
Bewegungsapparat
Cervical vertebral compressive myelopathy, commonly known as Wobbler syndrome, is a condition affecting the spine where the spinal cord in the neck becomes pinched. This compression is caused by malformed neck vertebrae or slipping discs between the bones. Over time, the constant pressure damages the nerve pathways that carry signals from the brain to the limbs.
Roentgen · Passing: A
Hip dysplasia(HD)
Bewegungsapparat
Hip dysplasia is an inherited skeletal disorder where the ball and socket of the hip joint do not fit together properly. Instead of sliding smoothly, the bones rub and grind against each other, wearing down the protective cartilage. Over time, this chronic friction causes joint instability, painful inflammation, and progressive arthritis, which is the gradual wear and tear of the joint.
Roentgen · Passing: C or better
Aortic valve stenosis(AS)
Herz
Aortic stenosis is a narrowing of the aortic valve in the heart, which controls blood flow from the main pumping chamber (the left ventricle) to the rest of the body. Because of this restriction, the heart muscle must work much harder to pump blood, which eventually causes the muscle wall to thicken abnormally. This is a severe cardiovascular condition that can strain the heart over time.
Passing: NORMAL
Mitral valve dysplasia(MVD)
Herz
Mitral valve dysplasia is a congenital heart defect where the mitral valve, which acts as a one-way gate on the left side of the heart, does not form correctly. This malformation prevents the valve from closing tightly, allowing blood to leak backward instead of pumping efficiently to the body. Over time, this leakage strains the heart muscle, which can lead to heart enlargement and eventual heart failure.
Ultraschall · Passing: NORMAL
Persistent right aortic arch (vascular ring anomaly)(PRAA)
Herz
This is a congenital abnormality of the cardiovascular system where a blood vessel near the heart fails to dissolve during development. This persistent vessel forms a tight ring around the esophagus, which is the tube that carries food from the mouth to the stomach. This ring constricts the esophagus, preventing solid food from passing through properly.
Roentgen · Passing: B
Dilated cardiomyopathy(DCM)
Herz und Kreislauf
Dilated cardiomyopathy (DCM) is a severe disease of the heart muscle where the heart's chambers become stretched and enlarged. This stretching thins the heart walls, making it difficult for the heart to pump blood effectively to the rest of the body. Over time, this decreased pumping ability can lead to fluid buildup in the lungs or abdomen.
Ultraschall · Passing: NORMAL
Hypothyroidism
Hormonelles und Stoffwechsel
Hypothyroidism is an endocrine disorder where the thyroid gland, located in the neck, fails to produce enough thyroid hormones. These hormones are essential for regulating the body's metabolic rate, which is the speed at which cells convert nutrients into energy. When hormone levels are too low, the dog's entire metabolism slows down, affecting multiple organ systems.
Koerperfluessigkeiten · Passing: CARRIER
Megaesophagus(ME)
Verdauung und Darm
Megaesophagus is a disorder of the digestive system where the esophagus, the muscular tube connecting the throat to the stomach, becomes abnormally stretched and loses its muscle tone. Because these muscles can no longer contract to push food and liquid downward, meals become trapped in the tube. This trapped material is typically regurgitated, meaning it is passively cast back up before ever reaching the stomach.
Roentgen · Passing: A
These levels are a comparison framework, not an official certification. They help compare breeding programs at a glance.
A complete checklist with every mandatory and recommended test plus identity and rearing questions — take it with you.
Open the full checklistFor breeders
Machine-readable mating rules, minimum ages, scoring schemes, and what's required for HonestDog verification — as a printable guide.
Example rule — DNA-Identitätsnachweis
Both parents must be tested for DNA-Identitätsnachweis and show a passing result.
We compile mandatory tests from official breed regulations and veterinary databases — and check every uploaded certificate for authenticity.
L1 = mandatory under breed-club regulations. L2 = recommended or clinically indicated. L3 = lower prevalence. Every assignment carries a source and confidence rating.
VDH breeding regulations, CIDD (University of PEI), OMIA (University of Sydney), curated veterinary input.
Uploaded certificates are AI-extracted and reviewed by our team for authenticity, date, and result.
1 tests are currently mandatory under the relevant breed-club regulations. The most common are DNA-Identitätsnachweis. Every test must be completed before mating, and the result must fall within the threshold defined by the regulation.
See breeders who have already uploaded their mandatory tests for verification.
View verified breeders